Acnes bacteria are irritants to the skin and lead to microcomedo formations and results in inflammatory lesions.
Excess Dihydrotestosterone can cause many dermatological issues such as clogged pores and inflammation. Studies have shown that spironolactone reduces sebum excretion in the skin by about 30-50 percent and therefore is very effective in those with oily skin. Being an oral medication, it has the possibility to cause more side effects than topical treatments. The most common side effects are excess urination, menstrual irregularities (spotting etc.) and low blood pressure. The menstual irregularities are usually decreased in woman who are also taking oral hormonal contraceptives. Many compounding pharmacies make topical spironolactone which can sometimes help reduce side effects. It is not commercially available though at retail pharmacies. Antibiotics (Topical) When To Use/Place In Therapy As part of combination therapy for mild to severe acne. Topical antibiotics should never be the sole treatment for several reasons including the extended time it takes to see positive effects and the...